Gane sent a warburgia specimen from the present tanzania to verdcourt 1954 that had foliage similar to w. Petiole bases and shoot tips were used as explants. Warburgia ugandensis, also known as ugandan greenheart, is a species of evergreen tree native to africa. Its allelophathic nature can drastically reduced the crop production and aggressive dominance of this weed threatens. A drimane sesquiterpenoid lactone from warburgia salutaris. In vitro 12shete and leukotriene metabolism inhibitory. The sugar alcohol mannitol 3% has been reported as present gr1. This species has its habitat encroached and this has led to a notable decrease in its population size to the level that warrant some conservation efforts. Warburgia ugandensis bioassay of different plant parts concerning. Warburgia ugandensis bioassay of different plant parts. The stem and roots of warburgia ugandensis sprague are used as expectorant, for the common cold and against fever, malaria, stomachache, constipation and diarrhea 1, 2. Pdf phytochemical analysis of warburgia ugandensis sprague. Warburgia ugandensis sprague is a woody species in the family canellaceae and an important source of medicines in africa.
Phytochemical analysis of warburgia ugandensis sprague. In subsaharan africa, chronic kidney disease ckd is being recognized as a noncommunicable disease ncd with high morbidity and mortality. Safety and efficacy of prunus africana and warburgia. Stuhlmann collected warburgia from mpizi near pangani in the then tanganyika and named it w. Warburgia ugandensis phytochemical research projectifs research. The bark of warburgia ugandensis is widely used as a herbal medicine in kenya and africa stem bark powder is known to be active against microbes olila et al. In vitro effects of warburgia ugandensis, psiadia punctulata. Commercial maize has been selectively bred to produce high quantities of. Bioassayguided studies on the cytotoxic and in vitro. Warburgia bark has been commonly used as traditional medicines for the treatment of gastrointestinal disorders, cold, cough and sore throat, fever, malaria, respiratory and odontological problems in african countries. Diversity in the phytochemical profiles of warburgia ugandensis. Warburgia ugandensis extracts were generally more toxic table 2. This plant species is a very good source of alkaloids, flavonoids, saponins, tannins, and glycosides chah et al. Menispermaceae were tested for activity on leishmania major promastigotes strain iduke83 nlb144 and infected macrophages in vitro.
It has a reputation for facilitating blood circulation and dispersing blood stasis. Wood anatomy of pleodendron costaricense canellaceae. Warburgia ugandensis medicinal herb used for the treatment of diabetes, malaria and pneumonia in kisii region, southwest kenya global journal of pharmacology. Warburgia ugandensis is a multipurpose tree which is highly beneficial for its pharmaceutical properties and is. A comparative study of the stem bark drimane sesquiterpenes and leaf volatile oils of warburgia ugandensis and w. Phytochemistry and pharmacological studies on solanum. One new drimanetype sesquiterpenoid, named ugandenial a 1, was isolated from the ethyl acetate extract of the bark of warburgia ugandensis canellaceae together with eight known drimanetype sesquiterpenoids.
The spatial scale of influence may increase when plant defense compounds are secreted in soil, affecting colonization by mycorrhizal and soil fungi stinson et al. Warburgia ugandensis sprague canellaceae extracts from different populations across the kenyan rift valley abuto john otieno b. Warburgia ugandensis sprague family canellacea commonly known as ugandan greenheart or pepper bark tree, is a highly valued medicinal plant in traditional medicine with a broad spectrum of antimicrobial activity whose parts especially the leaves and stem bark have for long been used in the treatment and management of many diseases and health conditions such as stomachache, cough, toothache. Dragons blood is the name given to a deep red resin obtained from a variety of plant sources. Most of the african counties in which the plant species is found include. Warburgia ugandensis health effects and herbal facts. Molecules free fulltext ugandenial a, a new drimanetype. Phytochemical analysis of warburgia ugandensis sprague using fourier transform infrared ftir spectroscopy. This data set contains scores for 185 loci for 100 individuals of the warburgia ugandensis tree species a medicinal tree species native to eastern africa.
Warburgia ugandensis, psiadia punctulata and chasmanthera dependens had an ic50 of 1. Warburgia ugandensis sprague family canellaceae, commonly referred to as east african greenheart pepperbark tree is widely distributed in the lowland rainforests and upland dry evergreen forests of eastern and southern africa 1. Warburgia ugandensis sprague canellaceae, which is commonly known as zogdom in amharic, is characterized by its bitter and peppery taste. Warburgia ugandensis, also known as uganda greenheart, is a species of evergreen tree native to africa. Diversity in the phytochemical profiles of warburgia. Antimicrobial and cytotoxic activities of fresh leaf extracts of warburgia ugandensis z. Antibacterial and antifungal activities of extracts of. International journal of pharmacognosy and phytochemical research 2014. Warburgia ugandensis sprague, which belongs to a member of canellaceae family, is a small evergreen tree distributed in eastern and southern africa. Since the data set is a subset of a larger data set that originated from a study of several warburgia species, some of the loci did not produce bands for w. A comparative study of the stembark drimane sesquiterpenes and leaf volatile oils of warburgia ugandensis and w.
Phytochemistry solanum torvum has been extensively explored for its chemical constituents. Screening of extracts of zanthoxylum chalybeum and warburgia. Canellaceae is an important, overexploited african ethnomedicinal plant threatened with extinction in the wild. Extracts of warburgia ugandensis have been reported to show some antimalarial properties in animal models. Plant extracts from warburgia ugandensis sprague family. Warburgia ugandensis, sprague, also known as the east african greenheart, a canallaceae, is a species of evergreen tree common to east african forests7. Menispermaceae were tested for activity on leishmania major promastigotes strain iduke83. Abstract arun arora, deepak mahapatra, fourier transform infrared spectroscopy analysis of few medicinal plants of. Chromatography of extracts of warburgia ugandensis stem bark afforded compound 49169k, which was characterized as the sesquiterpine muzigadial by 1 hnmr spectroscopy, which did not show antibacterial activity but had. Alice njeri muchugi 5 on rooting and shoot formation of warburgia ugandensis stem cuttings african journal of plant science vol.
Compositae and chasmanthera dependens hoschst family. Warburgia ugandensis is an evergreen tree with a spreading, rounded crown. Warburgia ugandensis bioassay of different plant parts concerning the antimicrobial. This study describes an efficient regeneration protocol. Pdf a phytochemical basis for the potential use of. The resin extracted from stems of dracaena cochinchinensis is one such source of dragons blood. Pdf toxicology, phytochemistry, bioactive compounds and. The wood is resistant to insect attack and very strong. Sesquiterpenes from warburgia ugandensis and their. Ethnopharmacological potentials of warburgia ugandensis on.
Parthenium hysterophorus, members of the asteraceae family is a noxious weed in america, asia, africa and australia. A model for antimalarial drugs discovery 24 sl 30 robert byamukama cycloartane triterpenes from the leaves of neoboutonia macrocalyx l. Ms, drimane sesquiterpenes, sugars and sugar alcohols, were compared with bacterial and fungal endophyte communities trflp, dna clones, qpcr in leaves and roots of the pepper bark tree, warburgia ugandensis canellaceae. An efficient callusbased in vitro regeneration protocol for. The presence of biologically active drimane sesquiterpenoid lactone constituents in the leaves, here demonstrated, provides the rational basis for their substitution for bark in ethnomedicine.
The tree species also occurs in secondary bushlands, grasslands and termitaria. A phytochemical basis for the potential use of warburgia salutaris pepperbark tree leaves in the place of bark article pdf available january 2001 with 456 reads how we measure reads. Phytochemical tests in our laboratories indicated the presence of tannins. In vitro 12shete and leukotriene metabolism inhibitory activity of sesquiterpenes of warburgia ugandensis. Initially, verdcourt thought that the specimen was conspecific with w. Warburgia is a genus of plant in family canellaceae described as a genus in 1895. Warburgia ugandensis isa highly valuedmedicinal tree within east africa which is overexploited for its medicinal use among many communities. Kadu cac, schueler s, konrad sh, muluvi gm, eyogmatig o, muchugi a, williams vl, ramamonjisoa l, kapinga c, foahom b, katsvanga c, hafashimana d, obama c and.
It was commonly used for the yoke pole of oxwagons, the disselboom. The bark of warburgia ugandensis is widely used as a herbal medicine in kenya and africa. Pdf warburgia ugandensis sprague is one of the most utilized medicinal plants in kenya. Frontiers antimicrobial drimane sesquiterpenes and their. Commercial maize has been selectively bred to produce high quantities of defense compounds, the benzoxazinoids bxs. This tree species is also found in india and china 1, 3. Warburgia canellaceae species have a long history of ethnomedicinal uses in east, central and southern africa. Although locally common in some areas, the populations of this species have been wiped out in many areas due to the use of its bark by traditional healers for medicinal purposes against asthma, maralia and other ailments as well as skin cream.
In countries like tanzania, people access many sources, including traditional medicines, to meet their healthcare needs for ncds, but little is known about traditional medicine practices among people with ckd. Due to over exploitation for its medicinal uses, the. Most of the biological activities are attributed to the drimane sesquiterpenoids, including polygodial, warburganal, muzigadial, mukaadial and ugandensial, flavonoids and miscellaneous compounds present in the various species. In traditional chinese medicine, this resinous medicine is commonly prescribed to invigorate blood. Warburgia ugandensis kenyatta university repository. Polygodial, an antifungal potentiator journal of natural. Kenya,ethiopia and some parts of western africa the wood is resistant to insect attack and very strong. In southern africa, the medicinal plant warburgia salutaris is commonly used for the treatment of inflammatory and other diseases. Various parts fruit, leaves and roots are being in use for the isolation of a wide range of compounds. Kowalski and van staden 2001 and prunus africana are exploited, while the rhizome of alepidea amatymbica is used cunningham 1993.
Traditional medicine practices among community members with. Warburgia ugandensis sprague is one of the most utilized medicinal plants in kenya. Warbugia ugandensis kenya neem foundation herbal clinic. Warburgia ugandensis water extracts and fraction 27163d also showed antifungal activity against candida albicans. Antimicrobial and cytotoxic activities of fresh leaf extracts. Abraham abebe wube1, simon gibbons2, kaleab asres3, bernhard streit1, michael adams1, rudolf bauer1, franz bucar1 1 institute of pharmaceuticalsciences, department of pharmacognosy, university graz, of graz, austria. Due to overexploitation for its medicinal uses, the. Sabinet a phytochemical basis for the potential use of.
The stem bark has been widely used in east african ethnomedicine for the treatment of stomachache, constipation, toothache, cough, fever, muscle pains, weak joints and general body pains kokwaro, 1976, watt and breyerbrandwijk, 1962. Warburgia ugandensis is one of the ten species identified as high priority medicinal plants in kenya for detailed study. The ability of warburgia salutaris extracts to protect. In silico validation of two antiparasitic acetogenins 26 sl 32 mulaa, francis j. Warburgia ugandensis is commonly known as east african green woodgreenheartpepper bark tree and it is in the family canellaceae 23. Preliminary phytochemical analysis of leaf powder extracts. Pdf warburgia ugandensis sprague family canellacea commonly known as ugandan greenheart or pepper bark tree, is a highly valued. Ten individuals each were assessed from two locations east and west of the great rift valley, kenya, africa, which differed in humidity and. This weed is considered to be a cause of a spectrum of clinical patterns. Jan 22, 2019 warburgia ugandensis sprague is a woody species in the family canellaceae and an important source of medicines in africa. The cytotoxicity of the drugs on balbc peritoneal macrophage cells was insignificant as compared to the highly toxic drug of choice pentostam. In vitro effects of warburgia ugandensis, psiadia punctulata and chasmanthera dependens on leishmania major promastigotes. Variation in antimicrobial activity of warburgia ugandensis. Evidence for alteration of fungal endophyte community.
656 127 600 255 268 585 669 412 487 729 1164 534 919 1456 399 895 1349 182 114 670 133 103 549 453 168 443 1475 263 361 1337 112 431 1000 270